Surprisingly, the risk of diabetes associated with PPI use appeared to be highest in people with normal blood pressure and lower weight. The study authors also noted that when people stopped taking these drugs, the risk of diabetes fell, and it continued to do so even more over time. Study participants who used PPIs for up to two years had a 5% increased risk, and the risk rose 26% for those who took the drugs more than two years. The investigators tried to control for factors that might affect type 2 diabetes risk, including high blood pressure, weight and physical inactivity.īesides linking regular use of PPIs to an increased risk of type 2 diabetes, the researchers found that long-term use increased the odds, too. In the early 2000s, the questions expanded to include whether they had used a PPI two or more times a week. Participants provided information on their health and behaviors every two years. They included more than 176,000 women and nearly 29,000 men. health professionals that began in the 1970s and 1980s. The researchers relied on data from three long-term studies of U.S. It's important to note, however, that this study was not designed to prove a cause-and-effect relationship between PPIs and type 2 diabetes. Long-term use has previously been linked to a greater risk of bone fractures, kidney disease, digestive tract infections and stomach cancer.īased on the new findings, the researchers suggested that people taking PPIs for a long time should have their blood sugar monitored for changes that might indicate developing diabetes. They are among the top 10 drugs used worldwide. PPIs are available by prescription or over-the-counter to treat acid reflux, peptic ulcers and other digestive conditions. Jinqiu Yuan, a researcher from the Sun Yat-Sen University, Shenzhen, Guangdong, China, led the study. "Regular PPI use was likely to be associated with an increased risk of type 2 diabetes, particularly for those with prolonged use," the authors wrote in the report published online Sept. The researchers also found that the longer people used the drugs, the higher their odds of diabetes. health care professionals and found that regular use of PPIs (such as Aciphex, Nexium, Prilosec, Prevacid, Protonix) was associated with a 24% higher risk of developing type 2 diabetes. 2, 2020 (HealthDay News) - Often-used drugs called proton pump inhibitors (PPIs) ease heartburn symptoms, but a new study suggests they might also increase the risk of type 2 diabetes.Ĭhinese researchers drew on information from studies of more than 200,000 U.S. Common Heartburn Meds Tied to Higher Diabetes RiskįRIDAY, Oct.
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